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It have been reported that using Indian Ayurvedic system (using Cerrebro Flo containing Zingbar officinale, Asparagus racemosus, Terminalia chebula etc.) remarkable clinical improvement was observed. The range of imporvement in I.Q. varied from 10-25 and even more in some cases. Down Syndrome (DS), the most common genetic cause of mental retardation, results in characteristic physical and neuropsychological findings, including deficits indicated a defective cerebral perfusion in cases if DS. So far no study was indicated any modality which can improve defective cerebral perfusion in this cases.